Catalytic-independent roles of UTX-1 inC. elegansdevelopment
نویسندگان
چکیده
منابع مشابه
Catalytic-independent roles of UTX-1 in C. elegans development
We recently analyzed the functional roles of UTX-1 during development. utx-1 is an essential gene required for the correct embryonic and post-embryonic development of C. elegans, and it displays an H3K27me3 demethylase activity. Rescue experiments demonstrated that the enzymatic activity of UTX-1 is not relevant for its role in development. The phenotypes associated with loss of UTX-1 might, in...
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Epigenetic modifications influence gene expression and provide a unique mechanism for fine-tuning cellular differentiation and development in multicellular organisms. Here we report on the biological functions of UTX-1, the Caenorhabditis elegans homologue of mammalian UTX, a histone demethylase specific for H3K27me2/3. We demonstrate that utx-1 is an essential gene that is required for correct...
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ژورنال
عنوان ژورنال: Worm
سال: 2013
ISSN: 2162-4054
DOI: 10.4161/worm.22188